Pharmacokinetics, Safety, and Tolerability Evaluation of Single and Multiple Doses of GSK3342830 in Healthy Volunteers

Author:

Tenero David1,Farinola Nicholas1,Berkowitz Elchonon M.1,Tiffany Courtney A.1,Qian Yanwen1,Xue Zhengyu1,Raychaudhuri Aparna1,Gardiner David F.1

Affiliation:

1. GlaxoSmithKlineClinical Pharmacology Modeling & Simulation Collegeville PA USA

Funder

GlaxoSmithKline

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference24 articles.

1. United States Centers for Disease Control and Prevention.Antibiotic Resistance Threats in the United States 2013.http://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf. Accessed October 17 2018.

2. O'NeillJ.Tackling drug resistant infections globally: final report and recommendations.2016.https://amr-review.org/sites/default/files/160525_Final%20paper_with%20cover.pdf. Accessed October 17 2018.

3. World Health Organization.Antimicrobial resistance: global report on surveillance2014.http://www.who.int/drugresistance/documents/surveillancereport/en/. Accessed October 17 2018.

4. World Health Organization.Global priority list of antibiotic‐resistant bacteria to guide research discovery and development of new antibiotics.2017.http://www.who.int/medicines/publications/global-priority-list-antibiotic-resistant-bacteria/en/. Accessed October 17 2018.

5. Identification of “in vivo MICs” using pharmacokinetic (PK)/pharmacodynamic (PD) modeling of animal efficacy data with a catechol‐cephem antibiotic;Hoover J;ASM Microbe,2017

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