Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as Sm HDAC8 Inhibitors for the Treatment of Schistosomiasis-Reference-Cited by-同舟云学术

Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as Sm HDAC8 Inhibitors for the Treatment of Schistosomiasis

Published:2018-07-04 Issue:15 Volume:13 Page:1517-1529
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Bayer Theresa¹,Chakrabarti Alokta²,Lancelot Julien³,Shaik Tajith B.⁴,Hausmann Kristin¹,Melesina Jelena¹,Schmidtkunz Karin²,Marek Martin⁴,Erdmann Frank¹,Schmidt Matthias¹,Robaa Dina¹,Romier Christophe⁴,Pierce Raymond J.³,Jung Manfred²,Sippl Wolfgang¹^ORCID

Affiliation:

1. Institute of Pharmacy Martin Luther University of Halle-Wittenberg Wolfgang-Langenbeck-Str. 4 06120 Halle/Saale Germany

2. Institute of Pharmaceutical Sciences University of Freiburg 79104 Freiburg Germany

3. University of Lille CNRS Inserm, CHU Lille, Institut Pasteur de Lille, U1019—UMR 8204-CIIL-Centre d'Infection et d'Immunité de Lille 59000 Lille France

4. Département de Biologie Structurale Intégrative Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC) Université de Strasbourg CNRS INSERM 67404 Illkirch Cedex France

Funder

Seventh Framework Programme

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201800238

Reference46 articles.

1. Epigenetic control of gene function in schistosomes: a source of therapeutic targets?

2. Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

3. World Health Organization Weekly Epidemiological Record Vol. 84 pp. 445–452 October 23 2009 (http://www.who.int/wer/2009/wer8443/en/).

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