Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases-Reference-Cited by-同舟云学术

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

Published:2015-06-17 Issue:7 Volume:10 Page:1163-1173
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

von Nussbaum Franz,Li Volkhart M.-J.,Allerheiligen Swen,Anlauf Sonja,Bärfacker Lars,Bechem Martin,Delbeck Martina,Fitzgerald Mary F.,Gerisch Michael,Gielen-Haertwig Heike,Haning Helmut,Karthaus Dagmar,Lang Dieter,Lustig Klemens,Meibom Daniel,Mittendorf Joachim,Rosentreter Ulrich,Schäfer Martina,Schäfer Stefan,Schamberger Jens,Telan Leila A.,Tersteegen Adrian

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201500131/fullpdf

Reference48 articles.

1. Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

2. Neutrophils and Protease/Antiprotease Imbalance

3. Leukocyte Elastase

4. Proteases and lung injury

5. Neutrophil Elastase Contributes to Cigarette Smoke-Induced Emphysema in Mice

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