Synthesis and Biological Evaluation of 3‐Arylindazoles as Selective MEK4 Inhibitors-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 3‐Arylindazoles as Selective MEK4 Inhibitors

Published:2019-02-19 Issue:6 Volume:14 Page:615-620
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Deibler Kristine K.¹,Schiltz Gary E.²³⁴,Clutter Matthew R.⁴⁵⁶,Mishra Rama K.²³,Vagadia Purav P.²,O'Connor Matthew¹,George Mariam Donny⁵,Gordon Ryan⁷,Fowler Graham⁷,Bergan Raymond⁷,Scheidt Karl A.¹²³⁴⁵^ORCID

Affiliation:

1. Department of ChemistryNorthwestern University Evanston IL 60208 USA

2. Center for Molecular Innovation and Drug DiscoveryNorthwestern University Evanston IL 60208 USA

3. Department of PharmacologyNorthwestern University Chicago IL 60611 USA

4. Robert H. Lurie Comprehensive Cancer CenterFeinberg School of MedicineNorthwestern University Chicago IL 60611 USA

5. Chemistry of Life Process InstituteNorthwestern University Evanston IL 60208 USA

6. Department of Molecular BiosciencesNorthwestern University Evanston IL 60208 USA

7. Knight Cancer InstituteOregon Health & Science University Portland OR 97239 USA

Funder

National Cancer Institute

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900019

Reference35 articles.

2. Novel biomarkers for diagnosis, prognosis, targeted therapy and clinical trials

3. The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer

4. Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

5. Role of mitogen-activated protein kinase kinase 4 in cancer

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