Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase-Reference-Cited by-同舟云学术

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase

Published:2018-09-11 Issue:20 Volume:13 Page:2177-2188
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Kiss László E.¹^ORCID,Beliaev Alexandre¹^ORCID,Ferreira Humberto S.¹^ORCID,Rosa Carla P.¹^ORCID,Bonifácio Maria João²^ORCID,Loureiro Ana I.²^ORCID,Pires Nuno M.²^ORCID,Palma P. Nuno²^ORCID,Soares-da-Silva Patrício²³^ORCID

Affiliation:

1. Laboratory of Chemistry, Department of Research and Development; BIAL-Portela & Cª., S.A.; À Avenida da Siderurgia Nacional 4745-457 Coronado (S. Romão and S. Mamede) Portugal

2. Laboratory of Pharmacology, Department of Research and Development; BIAL-Portela & Cª., S.A.; À Avenida da Siderurgia Nacional 4745-457 Coronado (S. Romão and S. Mamede) Portugal

3. MedInUp-Center for Drug Discovery and Innovative Medicines; University of Porto; Praça Gomes Teixeira 4099-002 Porto Portugal

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201800393/fullpdf

Reference45 articles.

1. STRUCTURE AND FUNCTION OF FATTY ACID AMIDE HYDROLASE

2. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

3. The Endocannabinoid System: Drug Targets, Lead Compounds, and Potential Therapeutic Applications

4. Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

5. Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors

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