A Novel Prodrug of a γ-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer-Reference-Cited by-同舟云学术

A Novel Prodrug of a γ-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer

Published:2018-01-09 Issue:2 Volume:13 Page:155-163
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Ii Hiromi¹,Yoshiya Taku²^ORCID,Nakata Susumu¹,Taniguchi Keiko¹,Hidaka Koushi³,Tsuda Shugo²,Mochizuki Masayoshi²,Nishiuchi Yuji²⁴,Tsuda Yuko³,Ito Kosei⁵,Kageyama Susumu⁶,Yoshiki Tatsuhiro¹

Affiliation:

1. Department of Clinical Oncology; Kyoto Pharmaceutical University; Misasagi-Nakauchicho 5, Yamashina-ku Kyoto 607-8414 Japan

2. Peptide Institute Inc.; 7-2-9 Saito-Asagi Ibaraki-shi Osaka 567-0085 Japan

3. Faculty of Pharmaceutical Sciences; Cooperative Research Center of Life Sciences; Kobe Gakuin University; 1-1-3 Minatojima, Chuo-ku Kobe 650-8586 Japan

4. Present address: GlyTech Inc.; 134 Chudoji Minamimachi, KRP #1-109, Shimogyo-ku Kyoto 600-8813 Japan

5. Graduate School of Biomedical Sciences; Nagasaki University; 1-7-1 Sakamoto Nagasaki 852-8588 Japan

6. Department of Urology; Shiga University of Medical Science, Seta Tsukinowa-cho; Otsu Shiga 520-2192 Japan

Funder

Takeda Science Foundation

Japan Society for the Promotion of Science

Technology-Supporting Program for the Strategic Research Foundation at Private University

Kyoto Pharmaceutical University Found for Promotion of Scientific Research

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference32 articles.

1. Enzymic Formation of Pyrrolidone Carboxylic Acid from γ-Glutamyl Peptides

2. Isolation and properties of γ-L-glutamylcyclotransferase from human brain

3. Formation of 5-Oxoproline from Glutathione in Erythrocytes by the -Glutamyltranspeptidase-Cyclotransferase Pathway

4. The -Glutamyl Cycle: A Possible Transport System for Amino Acids

5. Glutathione Synthetase Deficiency, an Inborn Error of Metabolism Involving the -Glutamyl Cycle in Patients with 5-Oxoprolinuria (Pyroglutamic Aciduria)

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Myc upregulates Ggct, γ‐glutamylcyclotransferase to promote development of p53‐deficient osteosarcoma;Cancer Science;2024-06-26

2. Myc upregulates Ggct, γ-glutamylcyclotransferase to promote development ofp53-deficient osteosarcoma;2024-03-19

3. Oxidative Stress Induced Protein Aggregation via GGCT Produced Pyroglutamic Acid in Drug Resistant Glioblastoma;2024

4. Identification of c-Met as a novel target of γ-glutamylcyclotransferase;Scientific Reports;2023-07-24

5. Development of an activity-based chemiluminogenic probe for γ-glutamylcyclotransferase;Organic & Biomolecular Chemistry;2023