Discovery of N -Aryloxypropylbenzylamines as Voltage-Gated Sodium Channel NaV 1.2-Subtype-Selective Inhibitors-Reference-Cited by-同舟云学术

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Discovery of N -Aryloxypropylbenzylamines as Voltage-Gated Sodium Channel NaV 1.2-Subtype-Selective Inhibitors

Published:2019-02-12 Issue:5 Volume:14 Page:570-582
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

van der Peet Phillip L.¹^ORCID,Sandanayake Saman¹,Jarrott Bevyn²^ORCID,Williams Spencer J.¹^ORCID

Affiliation:

1. School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology; University of Melbourne; Parkville Victoria 3010 Australia

2. Florey Institute of Neuroscience & Mental Health; Parkville Victoria 3010 Australia

Funder

FastForward

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201800781/fullpdf

Reference31 articles.

1. The hitchhiker’s guide to the voltage-gated sodium channel galaxy

2. The pharmacology of voltage-gated sodium channel activators

3. Recent progress in sodium channel modulators for pain

4. The Pharmacology of Voltage-Gated Sodium Channels in Sensory Neurones

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1. Discovery of Novel Pyrimidine-Based Derivatives as Nav1.2 Inhibitors with Efficacy in Mouse Models of Epilepsy;Journal of Medicinal Chemistry;2024-07-22

2. Voltage-Gated Sodium Channels as Drug Targets in Epilepsy-Related Sodium Channelopathies;Ion Channels as Targets in Drug Discovery;2024

3. Advances in Epilepsy: Mechanisms, Clinical Trials, and Drug Therapies;Journal of Medicinal Chemistry;2023-04-04

4. Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship;Medicinal Chemistry;2021-11

5. Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C–H Activation Cascade with Dimethyl Carbonate as the Methyl Source;Journal of the American Chemical Society;2021-03-22

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