Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo-Reference-Cited by-同舟云学术

Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo

Published:2015-04-15 Issue:5 Volume:10 Page:815-826
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Grosskopf Stefanie,Eckert Chris,Arkona Christoph,Radetzki Silke,Böhm Kerstin,Heinemann Udo,Wolber Gerhard,von Kries Jens-Peter,Birchmeier Walter,Rademann Jörg

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201500015/fullpdf

Reference51 articles.

1. Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics

2. The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

3. The Tyrosine Phosphatase Shp2 in Development and Cancer

4. Crystal Structure of the Tyrosine Phosphatase SHP-2

5. Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2

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