Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast-Reference-Cited by-同舟云学术

Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

Published:2019-11-19 Issue:1 Volume:15 Page:50-67
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Schierle Simone¹,Helmstädter Moritz¹,Schmidt Jurema¹,Hartmann Markus¹,Horz Maximiliane¹,Kaiser Astrid¹,Weizel Lilia¹,Heitel Pascal¹^ORCID,Proschak Anna¹,Hernandez‐Olmos Victor²,Proschak Ewgenij¹,Merk Daniel¹^ORCID

Affiliation:

1. Institute of Pharmaceutical ChemistryGoethe University Frankfurt Max-von-Laue-Str. 9 60438 Frankfurt Germany

2. Fraunhofer Institute for Molecular Biology and Applied Ecology IMEBranch for Translational Medicine and Pharmacology TMP Theodor-Stern-Kai 7 60596 Frankfurt am Main Germany

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900576

Reference46 articles.

1. Farnesoid X receptor: from medicinal chemistry to clinical applications

2. Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators

3. Tissue-specific actions of FXR in metabolism and cancer

4. Therapies in non-alcoholic steatohepatitis (NASH)

5. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

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