Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A-Reference-Cited by-同舟云学术

Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A

Published:2015-09-04 Issue:11 Volume:10 Page:1875-1883
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Rüger Nicole¹,Roatsch Martin²,Emmrich Thomas¹,Franz Henriette³,Schüle Roland³,Jung Manfred²,Link Andreas¹

Affiliation:

1. Institute of Pharmacy; Ernst-Moritz-Arndt-Universität Greifswald; Friedrich-Ludwig-Jahn-Str. 17 17487 Greifswald Germany

2. Institute of Pharmaceutical Sciences; Albert-Ludwigs-Universität Freiburg; Albertstr. 25 79104 Freiburg Germany

3. University of Freiburg Medical Center; Department of Urology, Women's Hospital and Center for Clinical Research; Breisacher Str. 66 79106 Freiburg Germany

Funder

Deutsche Forschungsgemeinschaft

Studienstiftung des deutschen Volkes

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201500335/fullpdf

Reference52 articles.

1. Purification and assay protocols for obtaining highly active Jumonji C demethylases

2. Expanding chemical biology of 2-oxoglutarate oxygenases

3. Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G1/S transition

4. The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells

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