Single Amino Acid Replacement in G‐7039 Leads to a 70‐fold Increase in Binding toward GHS‐R1a-Reference-Cited by-同舟云学术

Single Amino Acid Replacement in G‐7039 Leads to a 70‐fold Increase in Binding toward GHS‐R1a

Published:2019-09-30 Issue:20 Volume:14 Page:1762-1766
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Lalonde Tyler¹²,Fowkes Milan M.¹²^ORCID,Hou Jinqiang³⁴,Thibeault Pierre E.⁵,Milne Mark⁶^ORCID,Dhanvantari Savita²⁷,Ramachandran Rithwik⁵^ORCID,Luyt Leonard G.¹²⁶⁸^ORCID

Affiliation:

1. Department of ChemistryUniversity of Western Ontario 1151 Richmond Street London ON N6A 5B7 Canada

2. Imaging ProgramLawson Health Research Institute 750 Base Line Road East London ON N6C 2R5 Canada

3. Department of ChemistryLakehead University 955 Oliver Road Thunder Bay ON P7B 5E1 Canada

4. Thunder Bay Regional Health Research Institute 980 Oliver Road Thunder Bay ON P7B 6V4 Canada

5. Department of Physiology and PharmacologyUniversity of Western Ontario Medical Sciences Building, Room 216 London ON N6A 5C1 Canada

6. London Regional Cancer ProgramLawson Health Research Institute 800 Commissioners Road East London ON N6A 5W9 Canada

7. Department of Medical BiophysicsUniversity of Western Ontario Medical Sciences Building, Room M407 London ON N6A 5C1 Canada

8. Department of OncologyUniversity of Western Ontario 800 Commissioners Road East London ON N6A 5W9 Canada

Funder

Natural Sciences and Engineering Research Council of Canada

Canadian Institutes of Health Research

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900466

Reference28 articles.

1. Ghrelin is a growth-hormone-releasing acylated peptide from stomach

2. Changes in the Cardiac GHSR1a-Ghrelin System Correlate With Myocardial Dysfunction in Diabetic Cardiomyopathy in Mice

3. Evidence Supporting a Role for the Blood-Cerebrospinal Fluid Barrier Transporting Circulating Ghrelin into the Brain

4. Dynamics of the Ghrelin/Growth Hormone Secretagogue Receptor System in the Human Heart Before and After Cardiac Transplantation

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