A Two‐Step Multicomponent Synthetic Approach and Anti‐inflammatory Evaluation of N ‐Substituted 2‐Oxopyrazines-Reference-Cited by-同舟云学术

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A Two‐Step Multicomponent Synthetic Approach and Anti‐inflammatory Evaluation of N ‐Substituted 2‐Oxopyrazines

Published:2018-12-12 Issue:1 Volume:14 Page:132-146
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Hernández‐Vázquez Eduardo¹^ORCID,Chávez‐Riveros Alejandra¹,Nieto‐Camacho Antonio¹,Miranda Luis D.¹

Affiliation:

1. Department of Organic Chemistry Instituto de Química UNAM, Circuito Exterior S.N. Ciudad Universitaria Coyoacán México, D.F. 04510 México

Funder

Fundación Marcos Moshinsky

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201800634

Reference39 articles.

1. Butrepyrazinone, a New Pyrazinone with an Unusual Methylation Pattern from a Ghanaian Verrucosispora sp. K51G

2. Maremycins C and D, New Diketopiperazines, and Maremycins E and F, Novel Polycyclicspiro-Indole Metabolites Isolated fromStreptomycessp.

3. ARGLECIN, A NEW MICROBIAL METABOLITE ISOLATION AND CHEMICAL STRUCTURE

4. Phevalin (aureusimine B)Production by Staphylococcus aureus Biofilm and Impacts on Human Keratinocyte Gene Expression

5. A Strategy to Minimize Reactive Metabolite Formation: Discovery of (S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a Potent, Orally Bioavailable Corticotropin-Releasing Factor-1 Receptor Antagonist

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1. Discovery of dual-action phenolic 4-arylidene-isoquinolinones with antioxidant and α-glucosidase inhibition activities;RSC Medicinal Chemistry;2024

2. Study on the Alleviating Effect and Potential Mechanism of Ethanolic Extract of Limonium aureum (L.) Hill. on Lipopolysaccharide-Induced Inflammatory Responses in Macrophages;International Journal of Molecular Sciences;2023-11-13

3. Discovery of Benzopyrrolizidines as Promising Antigiardiasic Agents;Frontiers in Cellular and Infection Microbiology;2022-01-12

4. Multicomponent synthesis and preliminary anti-inflammatory activity of lipophilic diphenylamines;Bioorganic & Medicinal Chemistry Letters;2021-04

5. Diversity-oriented synthesis and cytotoxic screening of fused dihydropyrazin-2(1H)-ones through a Ugi 4-CR/deprotection/Heck sequence;Tetrahedron;2020-09

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