Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase-Reference-Cited by-同舟云学术

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Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase

Published:2018-05-22 Issue:12 Volume:13 Page:1172-1180
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Larocque Elizabeth A.¹,Naganna N.¹,Opoku-Temeng Clement¹²^ORCID,Lambrecht Alyssa M.¹,Sintim Herman O.¹^ORCID

Affiliation:

1. Department of Chemistry; Purdue University; West Lafayette IN 47907 USA

2. Graduate Program in Biochemistry; University of Maryland; College Park MD 20742 USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201700829/fullpdf

Reference31 articles.

1. T315I-mutated Bcr-Abl in chronic myeloid leukemia and imatinib: insights from a computational study

2. Leukemia stem cells: the root of chronic myeloid leukemia

3. Development of an Effective Therapy for Chronic Myelogenous Leukemia

4. Attacking cancer at its foundation

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1. High-dose nicotinamide, a histone deacetylase inhibitor (Sirtuin-1), can prevent emergence of treatment resistance in chronic myeloid leukemia – A perspective;International Journal of Molecular and Immuno Oncology;2024-02-19

2. New Progress of Fully Continuous Flow Reaction Technologies in Pharmaceutical Synthesis (2019~2022);Chinese Journal of Organic Chemistry;2024

3. Identification by molecular dynamic simulation and in vitro validation of SISB-A1, N-[1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-yl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl) oxy], as an inhibitor of the AblT315I mutant kinase to combat imatinib resistance in chronic myeloid leukemia;Medical Oncology;2023-10-03

4. Isoquinoline Antimicrobial Agent: Activity against Intracellular Bacteria and Effect on Global Bacterial Proteome;Molecules;2022-08-10

5. The progress of small-molecules and degraders against BCR-ABL for the treatment of CML;European Journal of Medicinal Chemistry;2022-08

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