Substituted Aminoacetamides as Novel Leads for Malaria Treatment

Author:

Norcross Neil R.1,Wilson Caroline1,Baragaña Beatriz1,Hallyburton Irene1,Osuna‐Cabello Maria1,Norval Suzanne1,Riley Jennifer1,Fletcher Daniel1,Sinden Robert2,Delves Michael2,Ruecker Andrea2,Duffy Sandra3,Meister Stephan4,Antonova‐Koch Yevgeniya4,Crespo Benigno5,de Cózar Cristina5,Sanz Laura M.5,Gamo Francisco Javier5,Avery Vicky M.3,Frearson Julie A.1,Gray David W.1,Fairlamb Alan H.1,Winzeler Elizabeth A.4,Waterson David6,Campbell Simon F.6,Willis Paul A.6,Read Kevin D.1,Gilbert Ian H.1ORCID

Affiliation:

1. Drug Discovery UnitDivision of Biological Chemistry and Drug DiscoverySchool of Life SciencesUniversity of Dundee Dundee DD1 5EH UK

2. Imperial College South Kensington London SW7 2AZ UK

3. Discovery BiologyGriffith Institute for Drug DiscoveryGriffith University Nathan Queensland 4111 Australia

4. Department of PediatricsUniversity of California San Diego School of Medicine 9500 Gilman Drive 0741 La Jolla CA 92093 USA

5. GlaxoSmithKline, Diseases of the Developing World – Tres Cantos Medicines Development Campus c/ Severo Ochoa 2, Tres Cantos 28760 Madrid Spain

6. Medicines for Malaria VentureInternational Centre, Cointrin, Entrance G, 3rd Floor Route de Pré-Bois 20, PO Box 1826 Geneva 1215 Switzerland

Funder

Wellcome Trust

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference19 articles.

1. Erratum: Antimalarial drug discovery — approaches and progress towards new medicines

2. World Malaria Report 2018 World Health Organization:https://www.who.int/malaria/publications/world-malaria-report-2018/report/en/(last access June 13 2019).

3. Malaria

4. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

5. Defining the biology component of the drug discovery strategy for malaria eradication

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