Discovery of Small‐Molecule Antibiotics against a Unique tRNA‐Mediated Regulation of Transcription in Gram‐Positive Bacteria

Author:

Frohlich Kyla M.12,Weintraub Spencer F.13,Bell Janeen T.14,Todd Gabrielle C.1,Väre Ville Y. P.1,Schneider Ryan5,Kloos Zachary A.167,Tabe Ebot S.68,Cantara William A.19,Stark Caren J.1,Onwuanaibe Urenna J.1,Duffy Bryan C.1011,Basanta‐Sanchez Maria112,Kitchen Douglas B.10,McDonough Kathleen A.56,Agris Paul F.113ORCID

Affiliation:

1. The RNA Institute and the Department of Biological SciencesUniversity at Albany – State University of New York 1400 Washington Avenue Albany NY 12222 USA

2. Current address: Regeneron Inc. Rensselaer NY USA

3. Current address: New York Medical College Valhalla NY USA

4. Current address: Albany Medical CollegeCenter for Physician Assistant Studies Albany NY USA

5. Department of Biomedical SciencesSchool of Public HealthUniversity at Albany – State University of New York P.O. Box 22002 Albany NY 12201 USA

6. Division of Infectious DiseasesWadsworth CenterNew York State Department of Health P.O. Box 22002 Albany NY 12201-2002 USA

7. Current address: Molecular, Cellular and Developmental BiologyYale University West Haven CT USA

8. Current address: Albany College of Pharmacy and Health Sciences Albany NY USA

9. Current address: Chemistry and BiochemistryOhio State University Columbus OH USA

10. Albany Molecular Research Incorporated 26 Corporate Circle Albany NY 12203 USA

11. Current address: New York State Department of Health Albany NY USA

12. Current address: Waters Corporation Pleasanton CA USA

13. Current address: Duke UniversityMedical School Durham NC USA

Funder

State of New York Technology Acceleration Fund

State of New York Health Network of Excellence

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference93 articles.

1. 1. Antibiotic/Antimicrobial Resistance Threats in the United States 2013 US Centers for Disease Control and Prevention

2. 2. (CDC):http://www.cdc.gov/drugresistance/threat-report-2013(accessedSeptember162013).

3. Targeting the bacteria–host interface

4. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

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