Identification of KPNB1 as a Cellular Target of Aminothiazole Derivatives with Anticancer Activity-Reference-Cited by-同舟云学术

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Identification of KPNB1 as a Cellular Target of Aminothiazole Derivatives with Anticancer Activity

Published:2016-05-31 Issue:13 Volume:11 Page:1406-1409
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Kim Yong-Hak¹,Ha Siyoung²,Kim Jungwon²,Ham Seung Wook²

Affiliation:

1. Department; Catholic University of Daegu School of Medicine; 3056-6 Daemyeong 4-dong Nam-gu Daegu 705-718 Republic of Korea

2. Department of Chemistry; Chung-Ang University; 221 Heakseok-dong Dongjak-gu Seoul 156-756 Republic of Korea

Funder

Chung-Ang University Excellent Student Scholarship in 2014

Basic Science Research Program

National Research Foundation of Korea

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference32 articles.

1. N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent

2. 2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent pan-Src Kinase Inhibitor

3. Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo

4. Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

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1. Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity;ACS Chemical Biology;2024-01-05

2. KPNB1-mediated nuclear import in cancer;European Journal of Pharmacology;2023-09

3. Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy;IUBMB Life;2023-08-25

4. Protein-protein docking analysis reveals efficient binding and complex formation between the human nuclear transport proteins;2021-03-22

5. Inhibition of NUPR1–Karyopherin β1 Binding Increases Anticancer Drug Sensitivity;International Journal of Molecular Sciences;2021-03-10

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