Discovery and Biophysical Evaluation of First Low Nanomolar Hits Targeting CYP125 ofM. tuberculosis-Reference-Cited by-同舟云学术

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Discovery and Biophysical Evaluation of First Low Nanomolar Hits Targeting CYP125 ofM. tuberculosis

Published:2016-09-28 Issue:21 Volume:11 Page:2385-2391
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Brengel Christian¹,Thomann Andreas¹,Schifrin Alexander²,Eberhard Jens¹,Hartmann Rolf W.¹³

Affiliation:

1. Helmholtz Institute for Pharmaceutical Research Saarland; Department of Drug Design and Optimization; Campus E8.1 66123 Saarbrücken Germany

2. Department of Biochemistry; Saarland University; Campus B2.2 66123 Saarbrücken Germany

3. Department of Pharmacy, Pharmaceutical and Medicinal Chemistry; Saarland University; Campus C2.3 66123 Saarbrücken Germany

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference48 articles.

1. Tuberculosis therapy: past, present and future

2. Advances in the development of new tuberculosis drugs and treatment regimens

3. 2014

4. The challenge of new drug discovery for tuberculosis

5. Identification of Mycobacterial Genes That Alter Growth and Pathology in Macrophages and in Mice

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1. Synthesis of steroidal inhibitors for Mycobacterium tuberculosis;The Journal of Steroid Biochemistry and Molecular Biology;2024-05

2. Rational development of mycobacteria cell factory for advancing the steroid biomanufacturing;World Journal of Microbiology and Biotechnology;2022-08-17

3. Structure‐Activity Relationship and Mode‐Of‐Action Studies Highlight 1‐(4‐Biphenylylmethyl)‐1 H ‐imidazole‐Derived Small Molecules as Potent CYP121 Inhibitors;ChemMedChem;2021-06-22

4. Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?;Applied Microbiology and Biotechnology;2019-02-27

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