Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants-Reference-Cited by-同舟云学术

Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants

Published:2018-03-15 Issue:8 Volume:13 Page:803-815
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Ghosh Arun K.¹^ORCID,Rao Kalapala Venkateswara¹,Nyalapatla Prasanth R.¹,Kovela Satish¹,Brindisi Margherita¹,Osswald Heather L.¹,Sekhara Reddy Bhavanam¹,Agniswamy Johnson²,Wang Yuan-Fang²,Aoki Manabu³⁴⁵,Hattori Shin-ichiro⁵,Weber Irene T.²,Mitsuya Hiroaki³⁴⁵

Affiliation:

1. Department of Chemistry and Department of Medicinal Chemistry; Purdue University; West Lafayette IN 47907 USA

2. Departments of Biology and Chemistry, Molecular Basis of Disease; Georgia State University; Atlanta GA 30303 USA

3. Departments of Hematology and Infectious Diseases; Kumamoto University School of Medicine; Kumamoto 860-8556 Japan

4. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch; National Cancer Institute; Bethesda MD 20892 USA

5. Center for Clinical Sciences; National Center for Global Heath and Medicine; Shinjuku Tokyo 162-8655 Japan

Funder

National Institute of General Medical Sciences

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference58 articles.

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4. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study

5. International AIDS Society global scientific strategy: towards an HIV cure 2016

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