Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP)-Reference-Cited by-同舟云学术

Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP)

Published:2016-03-10 Issue:12 Volume:11 Page:1380-1394
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Schwarz Theresa¹^ORCID,Montanari Floriane¹^ORCID,Cseke Anna¹,Wlcek Katrin¹,Visvader Lene¹,Palme Sarah¹,Chiba Peter²,Kuchler Karl³,Urban Ernst¹,Ecker Gerhard F.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry; Faculty of Life Sciences; University of Vienna; Althanstraße 14 1090 Vienna Austria

2. Department of Medicinal Chemistry; Medical University Vienna; Währingerstraße 10 1090 Vienna Austria

3. Department of Medical Biochemistry; Max F. Perutz Laboratories; Medical University Vienna; Dr. Bohr-Gasse 9/2 1030 Vienna Austria

Funder

Austrian Science Fund (FWF)

Hochschuljubiläumsstiftung

Innovative Medicines Initiative Joint Undertaking

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference47 articles.

1. The Human ATP-Binding Cassette (ABC) Transporter Superfamily

2. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

3. Transporters and Drug-Drug Interactions: Important Determinants of Drug Disposition and Effects

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