Optimization of the Antiviral Potency and Lipophilicity of Halogenated 2,6-Diarylpyridinamines as a Novel Class of HIV-1 NNRTIS-Reference-Cited by-同舟云学术

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Optimization of the Antiviral Potency and Lipophilicity of Halogenated 2,6-Diarylpyridinamines as a Novel Class of HIV-1 NNRTIS

Published:2014-06-04 Issue:7 Volume:9 Page:1546-1555
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Wu Zhi-Yuan,Liu Na,Qin Bingjie,Huang Li,Yu Fei,Qian Keduo,Morris-Natschke Susan L.,Jiang Shibo,Chen Chin Ho,Lee Kuo-Hsiung,Xie Lan

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201400075/fullpdf

Reference24 articles.

1. Antiretroviral therapy of HIV-1 infection: established treatment strategies and new therapeutic options

2. Antiretroviral therapy: state of the HAART

3. Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

4. TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments

5. Rilpivirine resistance mutations in HIV patients failing non-nucleoside reverse transcriptase inhibitor-based therapies

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2. In Vitro and In Silico Antiviral Activity of Di-Halogenated Compounds Derived from L-Tyrosine against Human Immunodeficiency Virus 1 (HIV-1);Current Issues in Molecular Biology;2023-10-09

3. Pyridine/Pyrimidine Substituted Imidazol-5-one Analogs as HIV-1 RT Inhibitors: Design, Synthesis, Docking and Molecular Dynamic Simulation Studies;Current HIV Research;2021-12-22

4. Discovery of novel furo[2,3‐ d ]pyrimidin‐2‐one–1,3,4‐oxadiazole hybrid derivatives as dual antiviral and anticancer agents that induce apoptosis;Archiv der Pharmazie;2021-06-15

5. Anti-HIV potential of diarylpyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors: design, synthesis, docking, TOPKAT analysis and molecular dynamics simulations;Journal of Biomolecular Structure and Dynamics;2020-04-11

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