Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3‐Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1-Reference-Cited by-同舟云学术

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Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3‐Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1

Published:2019-05-08 Issue:12 Volume:14 Page:1135-1151
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Schaarschmidt Maren¹,Höfner Georg¹,Wanner Klaus T.¹^ORCID

Affiliation:

1. Department of Pharmacy—Center for Drug ResearchLudwig-Maximilians-Universität München Butenandtstr. 7–13 81377 Munich Germany

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900170

Reference43 articles.

1. GABAergic Mechanisms in Epilepsy

2. GABAAreceptors in aging and Alzheimer’s disease

3. Role of GABA in anxiety and depression

4. Tiagabine and Gabapentin for the Management of Chronic Pain

5. GLIA/ASTROCYTES | Glial Modulation of Excitability via Glutamate and GABA Transporters

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1. Synthesis of Functionalized Tetrasubstituted Allenes by the Addition of Bis(trimethylsilyl)ketene Acetals to Ynones Catalyzed by Gold(I);The Journal of Organic Chemistry;2024-02-15

2. Allenation of Terminal Alkynes for Allene Synthesis;Homologation Reactions;2023-05-26

3. Alternative Synthesis of the Alkaloid Guvacine and Its Derivatives;Russian Journal of Organic Chemistry;2022-06

4. Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies;European Journal of Medicinal Chemistry;2022-04

5. Synthesis of methyl(ethyl) pyrazolo[4,3-b]pyridine-6-carboxylates and their conversion to tert-butyl 4,5,6,7-tetrahydropyrazolo-[4,3-b]pyridine-6-carboxylates;Chemistry of Heterocyclic Compounds;2021-11

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