From Type I to Type II: Design, Synthesis, and Characterization of Potent Pyrazin-2-ones as DFG-Out Inhibitors of PDGFRβ-Reference-Cited by-同舟云学术

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From Type I to Type II: Design, Synthesis, and Characterization of Potent Pyrazin-2-ones as DFG-Out Inhibitors of PDGFRβ

Published:2016-11-25 Issue:24 Volume:11 Page:2664-2674
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Bethke Eugen¹,Pinchuk Boris¹,Renn Christian¹,Witt Lydia¹,Schlosser Joachim¹,Peifer Christian¹^ORCID

Affiliation:

1. Christian Albrechts University of Kiel; Institute of Pharmacy; Gutenbergstr. 76 24118 Kiel Germany

Funder

Deutsche Forschungsgemeinschaft (DFG)

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference59 articles.

1. Small-molecule kinase inhibitors: an analysis of FDA-approved drugs

2. Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes

3. Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery?

4. Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features

5. Targeting Gain of Function and Resistance Mutations in Abl and KIT by Hybrid Compound Design

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1. Targeting EphA2: a promising strategy to overcome chemoresistance and drug resistance in cancer;Journal of Molecular Medicine;2024-02-23

2. Molecular Modeling of Protein Kinases: Current Status and Challenges;Proteinkinase Inhibitors;2020

3. Nucleophilic and electrophilic cyclization of N-alkyne-substituted pyrrole derivatives: Synthesis of pyrrolopyrazinone, pyrrolotriazinone, and pyrrolooxazinone moieties;Beilstein Journal of Organic Chemistry;2017-05-04

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