Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma-Reference-Cited by-同舟云学术

Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma

Published:2018-04-06 Issue:9 Volume:13 Page:957-967
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

De Gasparo Raoul¹,Brodbeck-Persch Elke¹,Bryson Steve²³,Hentzen Nina B.¹,Kaiser Marcel⁴⁵,Pai Emil F.²³^ORCID,Krauth-Siegel R. Luise⁶,Diederich François¹^ORCID

Affiliation:

1. Laboratorium für Organische Chemie; ETH Zürich; Vladimir-Prelog-Weg 3 8093 Zürich Switzerland

2. Departments of Biochemistry, Medical Biophysics, and Molecular Genetics; University of Toronto; Medical Sciences Building, #5358, 1 King's College Circle Toronto ON M5S 1A8 Canada

3. The Campbell Family Institute for Cancer Research; University Health Network; 101 College Street Toronto ON M5G 1L7 Canada

4. Swiss Tropical and Public Health Institute; Socinstrasse 57 4002 Basel Switzerland

5. University of Basel; Petersplatz 1 4003 Basel Switzerland

6. Biochemie-Zentrum Heidelberg (BZH); Universität Heidelberg; Im Neuenheimer Feld 328 69120 Heidelberg Germany

Funder

ETH Research Council

Deutsche Forschungsgemeinschaft

National Science and Engineering Research Council of Canada

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

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