Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists-Reference-Cited by-同舟云学术

Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists

Published:2019-11-05 Issue:22 Volume:14 Page:1917-1932
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Sato Ayumu¹²^ORCID,Fukase Yoshiyuki¹³,Kono Mitsunori¹,Ochida Atsuko¹,Oda Tsuneo¹,Sasaki Yusuke¹,Ishii Naoki¹,Tomata Yoshihide¹,Fukumoto Shoji¹⁴,Imai Yumi N.¹⁵,Uga Keiko¹²,Shibata Akira¹,Yamasaki Masashi¹²,Nakagawa Hideyuki¹,Shirasaki Mikio¹²,Skene Robert⁶,Hoffman Isaac⁶,Sang Bi‐Ching⁶,Snell Gyorgy⁶,Shirai Junya¹⁷,Yamamoto Satoshi¹

Affiliation:

1. Pharmaceutical Research DivisionTakeda Pharmaceutical Company Ltd. 26-1, Muraokahigashi 2-chome, Fujisawa Kanagawa 251-8555 Japan

2. Axcelead Drug Discovery Partners, Inc. 26-1, Muraoka-Higashi 2-Chome, Fujisawa Kanagawa 251-0012 Japan

3. Tri-Institutional Therapeutics Discovery Institute, Inc. 413 East 69th Street New York NY 10021 USA

4. Japan Tobacco Inc.Central Pharmaceutical Research Institute 1-1 Murasaki-cho Takatsuki, Osaka 569-1125 Japan

5. Chordia Therapeutics Inc. 26-1, Muraoka-Higashi 2-Chome, Fujisawa Kanagawa 251-0012 Japan

6. Takeda California, Inc.10410 Science Center Drive San Diego CA 92121 USA

7. Cardurion Pharmaceuticals K.K. 26-1, Muraokahigashi 2-chome, Fujisawa Kanagawa 251-8555 Japan

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900416

Reference96 articles.

1. ROR-γ: The Third Member of ROR/RZR Orphan Receptor Subfamily That Is Highly Expressed in Skeletal Muscle

2. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

4. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

5. A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Modes of action insights from the crystallographic structures of retinoic acid receptor-related orphan receptor-γt (RORγt);European Journal of Medicinal Chemistry;2023-02

2. Statistical Analysis of Protein-Ligand Interaction Patterns in Nuclear Receptor RORγ;Frontiers in Molecular Biosciences;2022-06-15

3. Crystallographic landscape provides molecular insights into the modes of action of diverse ROR-γt modulators;Drug Discovery Today;2022-02

4. The evolution paths of some reprehensive scaffolds of RORγt modulators, a perspective from medicinal chemistry;European Journal of Medicinal Chemistry;2022-01

5. Retinoic acid-related orphan receptor gamma t (RORγt) inverse agonists/antagonists for the treatment of inflammatory diseases – where are we presently?;Expert Opinion on Drug Discovery;2021-07-07