Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI-Reference-Cited by-同舟云学术

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

Published:2016-01-26 Issue:4 Volume:11 Page:367-373
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Jarvis Cassie¹,Han Zhenfu¹,Kalas Vasilios²,Klein Roger²,Pinkner Jerome S.²,Ford Bradley²,Binkley Jana²,Cusumano Corinne K.²,Cusumano Zachary³,Mydock-McGrane Laurel³,Hultgren Scott J.²⁴,Janetka James W.¹⁴

Affiliation:

1. Washington University School of Medicine; Department of Biochemistry and Molecular Biophysics; 660 S. Euclid Ave. St. Louis MO 63110 USA

2. Washington University School of Medicine; Department of Molecular Microbiology; 660 S. Euclid Ave. St. Louis MO 63110 USA

3. Fimbrion Therapeutics Inc.; 4041 Forest Park Ave. St. Louis MO 63108 USA

4. Washington University School of Medicine; Center for Women's Infectious Disease Research (cWIDR); 660 S. Euclid Ave. St. Louis MO 63110 USA

Funder

National Institutes of Health (NIH)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

National Institute of Allergy and Infectious Diseases (NIAID)

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201600006/fullpdf

Reference31 articles.

1. Urinary tract infections: epidemiology, mechanisms of infection and treatment options

2. Persistence of Uropathogenic Escherichia coli in the Face of Multiple Antibiotics

3. Insights into a Multidrug Resistant Escherichia coli Pathogen of the Globally Disseminated ST131 Lineage: Genome Analysis and Virulence Mechanisms

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