Allosteric p97 Inhibitors Can Overcome Resistance to ATP‐Competitive p97 Inhibitors for Potential Anticancer Therapy-Reference-Cited by-同舟云学术

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Allosteric p97 Inhibitors Can Overcome Resistance to ATP‐Competitive p97 Inhibitors for Potential Anticancer Therapy

Published:2020-03-23 Issue:8 Volume:15 Page:685-694
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Wang. Feng¹²,Li Shan¹²,Gan Taiping¹,Stott Gordon M.³,Flint Andrew³,Chou Tsui‐Fen¹²^ORCID

Affiliation:

1. Division of Medical Genetics, Department of Pediatrics Harbor-UCLA Medical Center and The Lundquist Institute Torrance CA 90502 USA

2. Current address: Division of Biology and Biological Engineering California Institute of Technology Pasadena CA 91125 USA

3. Leidos Biomedical Research Inc. Frederick MD 21702 USA

Funder

National Cancer Institute

National Institutes of Health

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900722

Reference33 articles.

1. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

2.

3. Expression Level of Valosin-Containing Protein (p97) Is Correlated With Progression and Prognosis of Non-Small-Cell Lung Carcinoma

4. Expression Level of Valosin-Containing Protein Is Strongly Associated With Progression and Prognosis of Gastric Carcinoma

5. Valosin-Containing Protein (p97) and Ki-67 Expression Is a Useful Marker in Detecting Malignant Behavior of Pancreatic Endocrine Neoplasms

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1. Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors;Communications Chemistry;2024-08-09

2. Exploring in vivo combinatorial chemo-immunotherapy: Addressing p97 suppression and immune reinvigoration in pancreatic cancer with tumor microenvironment-responsive nanoformulation;Biomedicine & Pharmacotherapy;2024-06

3. An innovative nanoformulation utilizing tumor microenvironment-responsive PEG-polyglutamic coating and dynamic charge adjustment for specific targeting of ER stress inducer, microRNA, and immunoadjuvant in pancreatic cancer: In vitro investigations;International Journal of Biological Macromolecules;2024-01

4. The NRF2-p97-NRF2 negative feedback loop;Redox Biology;2023-09

5. Inhibition of VCP modulates NF-κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation;Aging;2023-08-21

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