Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure–Degradation Relationships-Reference-Cited by-同舟云学术

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Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure–Degradation Relationships

Published:2018-07-04 Issue:15 Volume:13 Page:1508-1512
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Burslem George M.¹^ORCID,Ottis Philipp¹,Jaime‐Figueroa Saul¹,Morgan Alicia²,Cromm Philipp M.¹,Toure Momar¹,Crews Craig M.¹³

Affiliation:

1. Department of Molecular, Cellular and Developmental Biology Yale University 219 Prospect Street New Haven CT 06520-8103 USA

2. Arvinas LLC 5 Science Park, 395 Winchester Avenue New Haven CT 06511 USA

3. Departments of Chemistry and Pharmacology Yale University New Haven CT USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201800271

Reference32 articles.

1. Treatment of Multiple Myeloma: A Comprehensive Review

2. Pomalidomide: A new IMiD with remarkable activity in both multiple myeloma and myelofibrosis

3. The evolution of thalidomide and its IMiD derivatives as anticancer agents

4. Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects

5. Thalidomide analogs and PDE4 inhibition

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