Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells

Author:

Dasari Ramesh1,De Carvalho Annelise2,Medellin Derek C.1,Middleton Kelsey N.1,Hague Frédéric3,Volmar Marie N. M.4,Frolova Liliya V.5,Rossato Mateus F.67,De La Chapa Jorge J.8,Dybdal-Hargreaves Nicholas F.9,Pillai Akshita10,Mathieu Véronique2,Rogelj Snezna5,Gonzales Cara B.8,Calixto João B.67,Evidente Antonio11,Gautier Mathieu3,Munirathinam Gnanasekar10,Glass Rainer4,Burth Patricia12,Pelly Stephen C.13,van Otterlo Willem A. L.13,Kiss Robert2,Kornienko Alexander1

Affiliation:

1. Department of Chemistry and Biochemistry; Texas State University; San Marcos TX 78666 USA

2. Laboratoire de Cancérologie et de Toxicologie Expérimentale; Faculté de Pharmacie; Université Libre de Bruxelles; 1050 Brussels Belgium

3. Laboratoire de Physiologie Cellulaire et Moléculaire; Faculté des Sciences; Université de Picardie Jules Verne; 80000 Amiens France

4. Neurosurgical Research; University Clinics Munich; Marchioninistr. 15 81377 Munich Germany

5. Departments of Chemistry and Biology; New Mexico Institute of Mining and Technology; 801 Leroy Place Socorro NM 87801 USA

6. Center of Innovation and Preclinical Studies; Av. Luiz Boiteux Piazza 1302, Cachoeira do Bom Jesus Florianópolis SC 88056-000 Brazil

7. Department of Pharmacology; Federal University of Santa Catarina; Florianópolis SC Brazil

8. Department of Comprehensive Dentistry; Cancer Therapy and Research Center; University of Texas Health Science Center at San Antonio; San Antonio TX 78229 USA

9. Department of Pharmacology; University of Texas Health Science Center at San Antonio; San Antonio TX 78229 USA

10. Department of Biomedical Sciences, College of Medicine; University of Illinois; 1601 Parkview Ave. Rockford IL 61107 USA

11. Dipartimento di Scienze Chimiche; Università di Napoli Federico II; Complesso Universitario Monte Sant'Angelo; Via Cintia 4 80126 Napoli Italy

12. Departamento de Biologia Celular e Molecular; Instituto de Biologia; Universidade Federal Fluminense; Outeiro de São João Batista, s/n Campus do Valonguinho Centro-Niterói RJ 24020-140 Brazil

13. Department of Chemistry and Polymer Science; Stellenbosch University; Stellenbosch Private Bag X1, Matieland 7602 South Africa

Funder

National Institute of General Medical Sciences

National Cancer Institute

Welch Foundation

National Science Foundation

NMT Presidential Research Support

National Research Foundation (NRF) of South Africa

Stellenbosch University

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

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