Synthesis and Biological Evaluation of N2-Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of N2-Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors

Published:2016-06-29 Issue:16 Volume:11 Page:1705-1708
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Cortese Daniela¹,Chegaev Konstantin¹,Guglielmo Stefano¹,Wang Lan Z.²,Golding Bernard T.³,Cano Céline³,Fruttero Roberta¹^ORCID

Affiliation:

1. Department of Drug Science and Technology; Università degli Studi di Torino; Via P. Giuria 9 10125 Turin Italy

2. Northern Institute for Cancer Research, Paul O'Gorman Building; Medical School; Newcastle University; Framlington Place Newcastle Upon Tyne NE2 4HH UK

3. Northern Institute for Cancer Research, Bedson Building; School of Chemistry; Newcastle University; Newcastle Upon Tyne NE1 7RU UK

Funder

Università degli Studi di Torino, Ricerca Locale 2014

Cancer Research UK

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference18 articles.

1. Cell cycle, CDKs and cancer: a changing paradigm

2. Mammalian cyclin-dependent kinases

3. Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2