Discovery, Optimization, and Biological Characterization of 2,3,6‐Trisubstituted Pyridine‐Containing M 4 Positive Allosteric Modulators-Reference-Cited by-同舟云学术

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Discovery, Optimization, and Biological Characterization of 2,3,6‐Trisubstituted Pyridine‐Containing M 4 Positive Allosteric Modulators

Published:2019-03-28 Issue:9 Volume:14 Page:943-951
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Schubert Jeffrey W.¹^ORCID,Harrison Scott T.¹,Mulhearn James¹,Gomez Robert¹,Tynebor Robert¹,Jones Kristen¹,Bunda Jaime¹,Hanney Barbara¹,Wai Jenny Miu‐Chen¹,Cox Chris¹,McCauley John A.¹,Sanders John M.²,Magliaro Brian³,O'Brien Julie³,Pajkovic Natasa⁴,Huszar Agrapides Sarah L.⁵,Taylor Anne⁵,Gotter Anthony⁶,Smith Sean M.⁶,Uslaner Jason⁶,Browne Susan⁵,Risso Stefania⁶,Egbertson Melissa¹

Affiliation:

1. Department of Medicinal ChemistryMerck & Co., Inc. West Point PA USA

2. Department of Computational and Structural ChemistryMerck & Co., Inc. West Point PA USA

3. Department of In Vitro PharmacologyMerck & Co., Inc. West Point PA USA

4. Department of Pharmacokinetics, Pharmacodynamics, and Drug MetabolismMerck & Co., Inc West Point PA USA

5. Department of In Vivo PharmacologyMerck & Co., Inc. West Point PA USA

6. Department of Neuroscience ResearchMerck & Co., Inc. West Point PA USA

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900088

Reference32 articles.

1. Best practice in the management of behavioural and psychological symptoms of dementia

2. Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease

3. Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia

4. Xanomeline and the Antipsychotic Potential of Muscarinic Receptor Subtype Selective Agonists

5. Classics in Chemical Neuroscience: Xanomeline

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1. Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M₄ mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders;Journal of Medicinal Chemistry;2024-07-18

2. Discovery of VU6008677: A Structurally Distinct Tricyclic M₄ Positive Allosteric Modulator with Improved CYP450 Profile;ACS Medicinal Chemistry Letters;2024-07-03

3. Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M₄ Muscarinic Acetylcholine Receptor;Journal of Medicinal Chemistry;2024-06-18

4. PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [¹¹C]MK-6884: Quantification with kinetic modeling and receptor occupancy by CVL-231 (emraclidine), a novel positive allosteric modulator;Journal of Cerebral Blood Flow & Metabolism;2024-03-13

5. 1,2,4‐Triazines and Calcium Carbide in the Catalyst‐Free Synthesis of 2,3,6‐Trisubstituted Pyridines and Their D‐, ¹³C‐, and Doubly D₂‐¹³C₂‐Labeled Analogues;Chemistry – An Asian Journal;2023-11-02

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