Potent Inhibitors ofPlasmodialSerine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold-Reference-Cited by-同舟云学术

Potent Inhibitors ofPlasmodialSerine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold

Published:2018-04-14 Issue:9 Volume:13 Page:931-943
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Schwertz Geoffrey¹^ORCID,Witschel Matthias C.²,Rottmann Matthias³⁴,Leartsakulpanich Ubolsree⁵,Chitnumsub Penchit⁵,Jaruwat Aritsara⁵,Amornwatcharapong Watcharee⁶,Ittarat Wanwipa⁵,Schäfer Anja³⁴,Aponte Raphael A.²,Trapp Nils¹,Chaiyen Pimchai⁶⁷,Diederich François¹^ORCID

Affiliation:

1. Laboratorium für Organische Chemie; ETH Zürich; Vladimir-Prelog-Weg 3 8093 Zürich Switzerland

2. BASF SE; Carl-Bosch-Strasse 38 67056 Ludwigshafen Germany

3. Swiss Tropical and Public Health Institute (SwissTPH); Socinstrasse 57 4051 Basel Switzerland

4. Universität Basel; Petersplatz 1 4003 Basel Switzerland

5. National Center for Genetic Engineering and Biotechnology; 113 Thailand Science Park, Phahonyothin Road Pathumthani 12120 Thailand

6. Department of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science; Mahidol University; 272 Rama VI Road Bangkok 10400 Thailand

7. Department of Biomolecular Science and Engineering, School of Biomolecular Science & Engineering; Vidyasirimedhi Institute of Science and Technology (VISTEC); Wangchan Valley Rayong 21210 Thailand

Funder

ETH Research Council

National Science and Technology development Agency (Thailand)

National Center for Genetic Engineering and Biotechnology

Thailand Research Fund

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference77 articles.

1. 2016 World Malaria Report 2016

2. Malaria