Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies-Reference-Cited by-同舟云学术

Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies

Published:2019-02-05 Issue: Volume: Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Ghosh Arun K.¹^ORCID,Brindisi Margherita¹,Yen Yu‐Chen²,Lendy Emma K.²,Kovela Satish¹,Cárdenas Emilio Leal¹,Reddy Bhavanam Sekhara¹,Rao Kalapala Venketeswara¹,Downs Deborah³,Huang Xiangping³,Tang Jordan³,Mesecar Andrew D.²

Affiliation:

1. Department of Chemistry and Department of Medicinal Chemistry and Molecular PharmacologyPurdue University West Lafayette IN 47907 USA

2. Department of BiochemistryPurdue University West Lafayette IN 47907 USA

3. Protein Studies ProgramOklahoma Medical Research FoundationDepartment of Biochemistry and Molecular BiologyUniversity of Oklahoma Health Science Center Oklahoma City OK 73104 USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201800725

Reference54 articles.

1. Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

2. Global and societal implications of the diabetes epidemic

3. Type 2 diabetes: principles of pathogenesis and therapy

4. IDF Diabetes Atlas – 8th Edition International Diabetes Federation:http://www.diabetesatlas.org/key-messages.html(accessed: April 1 2016).

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