Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor-Reference-Cited by-同舟云学术

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Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor

Published:2019-05-14 Issue:11 Volume:14 Page:1115-1127
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Dalvit Claudio¹,Parent Annick²,Vallée Francois²,Mathieu Magali²,Rak Alexey²^ORCID

Affiliation:

1. Lavis Trento Italy

2. Bio Structure and BiophysicsIntegrated Drug DiscoverySanofi R&D 13, Quai Jules Guesde—BP 14 94403 Vitry sur Seine Cedex France

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900152

Reference77 articles.

1. Twenty years on: the impact of fragments on drug discovery

2. Biophysics in drug discovery: impact, challenges and opportunities

3. An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery

4. NMR methods in fragment screening: theory and a comparison with other biophysical techniques

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