Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP)-Reference-Cited by-同舟云学术

Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP)

Published:2015-09-18 Issue:2 Volume:11 Page:217-233
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Lovering Frank¹,Aevazelis Cristina²,Chang Jeanne³,Dehnhardt Christoph¹,Fitz Lori²,Han Seungil³,Janz Kristin¹,Lee Julie²,Kaila Neelu¹,McDonald Joseph¹,Moore William¹,Moretto Alessandro¹,Papaioannou Nikolaos¹,Richard David¹,Ryan Mark S.²,Wan Zhao-Kui¹,Thorarensen Atli¹

Affiliation:

1. Worldwide Medicinal Chemistry; Pfizer Worldwide R&D; 610 Main Street Cambridge MA 02139 USA

2. Inflammation and Immunity; Pfizer Worldwide R&D; 610 Main Street Cambridge MA 02139 USA

3. Worldwide Medicinal Chemistry; Pfizer Worldwide R&D; Eastern Point Road Groton CT 06340 USA

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201500333/fullpdf

Reference40 articles.

1. Therapeutic Targeting of Syk in Autoimmune Diabetes

2. The Syk kinase as a therapeutic target in leukemia and lymphoma

3. The tyrosine kinase network regulating mast cell activation

4. Molecular Mechanism of the Syk Activation Switch

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