Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action

Author:

Boss Christoph1,Aissaoui Hamed1,Amaral Nathalie1,Bauer Aude1,Bazire Stephanie1,Binkert Christoph1,Brun Reto23,Bürki Cédric1,Ciana Claire-Lise14,Corminboeuf Olivier1,Delahaye Stephane1,Dollinger Claire1,Fischli Christoph23,Fischli Walter1,Flock Alexandre1,Frantz Marie-Céline15,Girault Malory1,Grisostomi Corinna1,Friedli Astrid1,Heidmann Bibia1,Hinder Claire1,Jacob Gael1,Le Bihan Amelie1,Malrieu Sophie1,Mamzed Saskia1,Merot Aurelien1,Meyer Solange1,Peixoto Sabrina1,Petit Nolwenn1,Siegrist Romain1,Trollux Julien1,Weller Thomas1,Wittlin Sergio23

Affiliation:

1. Actelion Pharmaceuticals Ltd.; Drug Discovery & Preclinical Development; Hegenheimermattweg 91 4123 Allschwil Switzerland

2. Swiss Tropical and Public Health Institute; Socinstrasse 57 4002 Basel Switzerland

3. University of Basel; Petersplatz 1 4001 Basel Switzerland

4. Sygnature Discovery Ltd., BioCity; Pennyfoot Street Nottingham NG1 1GF (UK)

5. L'Oréal Research & Innovation; 1 Avenue Eugène Schueller 93600 Aulnay-sous-Bois France

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

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