Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine-Reference-Cited by-同舟云学术

Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine

Published:2018-07-06 Issue:15 Volume:13 Page:1530-1540
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Hirano Tomoya¹^ORCID,Fujiwara Takashi¹,Niwa Hideaki²^ORCID,Hirano Michitake¹,Ohira Kasumi¹,Okazaki Yusuke¹,Sato Shin²,Umehara Takashi²^ORCID,Maemoto Yuki³,Ito Akihiro³⁴,Yoshida Minoru⁴⁵⁶,Kagechika Hiroyuki¹^ORCID

Affiliation:

1. Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai Chiyoda-ku Tokyo 101-0062 Japan

2. Epigenetics Drug Discovery Unit RIKEN Center for Life Science Technologies (CLST) 1-7-22 Suehiro-cho, Tsurumi-ku Yokohama 230-0045 Japan

3. School of Life Sciences Tokyo University of Pharmacy and Life Sciences 1432-1 Horinouchi Hachioji Tokyo 192-0392 Japan

4. Chemical Genomics Research Group RIKEN Center for Sustainable Resource Science (CSRS) 2-1 Hirosawa Wako Saitama 351-0198 Japan

5. Drug Discovery Platforms Cooperation Division RIKEN Center for Sustainable Resource Science (CSRS) 2-1 Hirosawa Wako Saitama 351-0198 Japan

6. Graduate School of Agricultural and Life Sciences The University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-8657 Japan

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201800233

Reference34 articles.

1. The Nucleosome

2. Epigenetics—An Epicenter of Gene Regulation: Histones and Histone-Modifying Enzymes

3. Epigenetik - ein Epizentrum der Genregulation: Histone und histonmodifizierende Enzyme

4. Regulation of chromatin structure by site-specific histone H3 methyltransferases

5. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

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