Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs-Reference-Cited by-同舟云学术

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs

Published:2017-08-31 Issue:18 Volume:12 Page:1542-1554
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Pirali Tracey¹^ORCID,Ciraolo Elisa²,Aprile Silvio¹,Massarotti Alberto¹^ORCID,Berndt Alex³,Griglio Alessia¹,Serafini Marta¹,Mercalli Valentina¹,Landoni Clarissa¹,Campa Carlo Cosimo²,Margaria Jean Piero²,Silva Rangel L.⁴,Grosa Giorgio¹,Sorba Giovanni¹,Williams Roger³,Hirsch Emilio²⁵,Tron Gian Cesare¹⁵^ORCID

Affiliation:

1. Dipartimento di Scienze del Farmaco; Università degli Studi del Piemonte Orientale “A. Avogadro”; Largo Donegani 2 28100 Novara Italy

2. Department of Molecular Biotechnology and Health Sciences; University of Torino; Via Nizza 52 10126 Torino Italy

3. MRC Laboratory of Molecular Biology; Medical Research Council; Cambridge CB2 0QH UK

4. Department of Pharmacology, Ribeirão Preto Medical School; University of São Paulo; Avenida Bandeirantes 3900 14049-900 Ribeirão Preto Brazil

5. Kither Biotech S.r.l.; Molecular Biotechnology Center; Via Nizza 52 10126 Torino Italy

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Regione Piemonte "Bando regionale a sostegno di progetti di ricerca industriale e/o sviluppo sperimentale sulle malattie autoimmuni e allergiche"

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference45 articles.

1. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

2. Class I PI 3-kinases: Function and evolution

3. Signaling by Distinct Classes of Phosphoinositide 3-Kinases

4. PI3K inhibitors in inflammation, autoimmunity and cancer

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