N -Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-d -xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase-Reference-Cited by-同舟云学术

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N -Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-d -xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase

Published:2017-03-22 Issue:7 Volume:12 Page:483-486
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Sevšek Alen¹,Šrot Luka¹,Rihter Jakob¹,Čelan Maša¹,van Ufford Linda Quarles¹,Moret Ed E.¹,Martin Nathaniel I.¹,Pieters Roland J.¹^ORCID

Affiliation:

1. Utrecht Institute for Pharmaceutical Sciences; Utrecht University; P.O. Box 3508 TB 3508 TB Utrecht The Netherlands

Funder

Slovenian Human Resources Development and Scholarship for Scientific Research

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference42 articles.

1. Iminosugars past, present and future: medicines for tomorrow

2. The route to diabetes: Loss of complexity in the glycemic profile from health through the metabolic syndrome to type 2 diabetes

3. Iminosugar derivative WGN-26 suppresses acute allograft rejection via inhibiting the IFN-γ/p-STAT1/T-bet signaling pathway

4. 1-Oxabicyclic β-lactams as new inhibitors of elongating MPT–a key enzyme responsible for assembly of cell-surface phosphoglycans of Leishmania parasite

5. Strain-specific antiviral activity of iminosugars against human influenza A viruses

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1. Targeting N-Acetylglucosaminidase in Staphylococcus aureus with Iminosugar Inhibitors;Antibiotics;2024-08-10

2. Recent advances in glycoside hydrolase family 20 and 84 inhibitors: Structures, inhibitory mechanisms and biological activities;Bioorganic Chemistry;2024-01

3. GCase Enhancers: A Potential Therapeutic Option for Gaucher Disease and Other Neurological Disorders;Pharmaceuticals;2022-07-02

4. Synthesis and Exploitation of the Biological Profile of Novel Guanidino Xylofuranose Derivatives**;ChemMedChem;2022-05-31

5. sp2-Iminosugars as chemical mimics for glycodrug design;Small Molecule Drug Discovery;2020

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