A (+)-Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6-Reference-Cited by-同舟云学术

A (+)-Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6

Published:2018-04-26 Issue:10 Volume:13 Page:1028-1035
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Häfner Stephanie¹^ORCID,Burg Finn²^ORCID,Kannler Martina³^ORCID,Urban Nicole¹,Mayer Peter²^ORCID,Dietrich Alexander³^ORCID,Trauner Dirk²⁴^ORCID,Broichhagen Johannes²⁵^ORCID,Schaefer Michael¹^ORCID

Affiliation:

1. Rudolf Boehm Institute for Pharmacology and Toxicology; Leipzig University; Härtelstr. 16-18 04107 Leipzig Germany

2. Department of Chemistry; Ludwig Maximilians University Munich and Center for Integrated Protein Science Munich; Butenandtstr. 5-13 81377 Munich Germany

3. Walther Straub Institute of Pharmacology and Toxicology; Ludwig Maximilians University Munich; Nußbaumstr. 26 80336 Munich Germany

4. Present address: Department of Chemistry, Silver Center for Arts and Science; New York University; 100 Washington Square East New York NY 10003 USA

5. Present address: Department of Chemical Biology; Max Planck Institute for Medical Research; Jahnstr. 29 69120 Heidelberg Germany

Funder

H2020 European Research Council

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference27 articles.

1. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

2. Regulation of Phosphoinositide-Specific Phospholipase C

3. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange