Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study-Reference-Cited by-同舟云学术

Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study

Published:2017-09-12 Issue:18 Volume:12 Page:1512-1524
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Peón Antonio¹^ORCID,Robles Adrián¹^ORCID,Blanco Beatriz¹^ORCID,Convertino Marino²³,Thompson Paul⁴^ORCID,Hawkins Alastair R.⁴,Caflisch Amedeo²^ORCID,González-Bello Concepción¹^ORCID

Affiliation:

1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares, CIQUS, and Departamento de Química Orgánica; Universidade de Santiago de Compostela; calle Jenaro de la Fuente s/n 15782 Santiago de Compostela Spain

2. Department of Biochemistry; University of Zurich; 8057 Zurich Switzerland

3. Current address: Department of Biochemistry and Biophysics; University of North Carolina, School of Medicine; Chapel Hill NC 27599 USA

4. Institute of Cell and Molecular Biosciences, Medical School; University of Newcastle upon Tyne; Catherine Cookson Building, Framlington Place Newcastle upon Tyne NE2 4HH UK

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia

European Regional Development Fund

Ministerio de Educación, Cultura y Deporte

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

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