A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis

Author:

Haupt Saskia12ORCID,Gleim Nils1ORCID,Ahadova Aysel34ORCID,Bläker Hendrik5ORCID,Knebel Doeberitz Magnus34ORCID,Kloor Matthias34ORCID,Heuveline Vincent12ORCID

Affiliation:

1. Engineering Mathematics and Computing Lab (EMCL) Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University Heidelberg Germany

2. Data Mining and Uncertainty Quantification (DMQ) Heidelberg Institute for Theoretical Studies (HITS) Heidelberg Germany

3. Department of Applied Tumor Biology (ATB) Institute of Pathology, University Hospital Heidelberg Heidelberg Germany

4. Clinical Cooperation Unit Applied Tumor Biology German Cancer Research Center Heidelberg Germany

5. Institute of Pathology University Hospital Leipzig Leipzig Germany

Publisher

Wiley

Subject

Industrial and Manufacturing Engineering,Polymers and Plastics,Business and International Management

Reference57 articles.

1. Classification of neuroendocrine neoplasms of the digestive system, WHO Classification of tumours, 5th Edition;Klimstra D.;Digestive system tumours,2019

2. Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

3. Microsatellite Instability

4. Biochemistry and genetics of eukaryotic mismatch repair;Kolodner R;Genes & Development,1996

5. Towards a multiscale model of colorectal cancer;Leeuwen Ingeborg MM;World Journal of Gastroenterology,2007

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