Kinetic and mechanistic investigation of the selective acidolysis of theC-terminal amide bond ofN-acyl-N,α,α-trialkyl glycine amides

Author:

Jiang Wei-Qun,Ventura Cristina,Costa Susana P.G.,Albuquerque Lídia,Gonçalves-Maia Raquel,Maia Hernâni L.S.

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

Reference13 articles.

1. Enhanced Protein Thermostability by Ala → Aib Replacement

2. , , , . Aminopeptidase M seems to jump over peptide bonds formed by N-terminal α,α-disubstituted amino acids. In Peptides 1998, , (eds). Akadémiai Kiadó: Budapest, 1999; 606-607.

3. N-Methylamino Acids in Peptide Synthesis. II. A New Synthesis of N-Benzyloxycarbonyl, N-Methylamino Acids

4. Redox N-Alkylation of Tosyl Protected Amino Acid and Peptide Esters.

5. , , , . Efficient preparation of Nα-alkylated amino acid and peptide derivatives via redox alkylation of suitable Nα-tosylated intermediates. In Peptides 1996, , (eds). Mayflower Scientific Ltd: Kingswinford (UK), 1997; 219-220.

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