Chalcogenide–Lewis Acid Mediated Tandem Michael Aldol Reaction — an Alternative to the Morita–Baylis–Hillman Reaction and a New Development

Author:

Kataoka Tadashi1,Kinoshita Hironori2

Affiliation:

1. Gifu Pharmaceutical University, 6‐1 Mitahora‐higashi 5‐chome, Gifu 502‐8585, Japan, Fax: (internat.) +81‐58‐237‐5979

2. Chemistry Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki 33‐94, Suita, Osaka 564‐0053, Japan, Fax: (internat.) +81‐6‐6338‐7656

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference128 articles.

1. This reaction is commonly called the Baylis–Hillman reaction. However Morita[1a 1b]reported thetert‐phosphane‐catalyzed reactions of electron‐deficient alkenes with aldehydes four years earlier than Baylis and Hillman.[1c]This has been pointed out by Drewes[1d]and Ciganek.[1f]Therefore the Baylis–Hillman reaction should be referred to as the Morita–Baylis–Hillman reaction.

2. A Tertiary Phosphine-catalyzed Reaction of Acrylic Compounds with Aldehydes

3. K.Morita Japan Patent68 03 364 (1968) [Chem. Abstr.1968 69 58828s].

4. A. B.Baylis M. E. D.Hillman Ger. Offen.2 155 113 (1972) [Chem. Abstr.1972 77 34174q]. Reviews for the Morita–Baylis–Hillman reaction:

5. Synthetic potential of the tertiary-amine-catalysed reaction of activated vinyl carbanions with aldehydes

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