Synthesis, Characterization, and Remarkable Biological Properties of Cyclodextrins Bearing Guanidinoalkylamino and Aminoalkylamino Groups on Their Primary Side-Reference-Cited by-同舟云学术

Synthesis, Characterization, and Remarkable Biological Properties of Cyclodextrins Bearing Guanidinoalkylamino and Aminoalkylamino Groups on Their Primary Side

Published:2008-05-09 Issue:14 Volume:14 Page:4188-4200
ISSN:0947-6539
Container-title:Chemistry - A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Mourtzis Nikolaos,Paravatou Maria,Mavridis Irene M.,Roberts Michael L.,Yannakopoulou Konstantina

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Reference62 articles.

1. Cyclodextrin chemistry. Selective modification of all primary hydroxyl groups of ?- and ?-cyclodextrins

2. Methods for Selective Modifications of Cyclodextrins

3. Synthesis of Per(5-carboxy-5-dehydroxymethyl)-α- and β-Cyclodextrins −Self-Assembly of the Per(2,3-di-O-methyl)-Protected Homologues into Highly Stable Dimers, Driven by Multiple Hydrogen Bonds

4. A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

5. A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

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