Affiliation:
1. Department of Physiology, Faculty of Medicine Chulalongkorn University and Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases Bangkok Thailand
2. Department of Medicine, Faculty of Medicine Chulalongkorn University Bangkok Thailand
Abstract
AbstractBackground and AimHelicobacter pylori (HP) infection remains a significant global public health problem. This study aimed to study the prevalence of HP infection and treatment outcomes in Thailand.MethodsWe retrospectively reviewed the results of the urea breath test (UBT) performed at the King Chulalongkorn Memorial Hospital between 2018 and 2021. The prevalence of HP infection was evaluated in dyspeptic patients undergoing UBT screening. In patients with known HP infection, the treatment regimen and the success rate in each patient were recorded.ResultsOne‐thousand nine‐hundred and two patients were included in this study. The prevalence of HP infection in dyspeptic patients was 20.77% (UBT was positive in 65 out of 313 patients). Of the 1589 patients who received the first treatment regimen, 1352 (85.08%) had a negative UBT result. Patients who failed in each treatment regimen were treated with subsequent regimens. The overall success rates for the second, third, and fourth regimens were 69.87% (109 of 156 patients), 53.85% (14 of 26 patients), and 50% (3 of 6 patients), respectively. Univariate logistic regression analysis found that using lansoprazole was associated with failure of treatment with OR = 2.11 (95% CI: 1.14–3.92, P = 0.018).ConclusionCurrent primary HP treatment regimens have an eradication rate of >80%. Even though the previous regimens failed, without available antibiotic sensitivity results, the subsequent regimens were successful by at least 50%. In cases of multiple‐treatment failure and where antibiotic sensitivity tests were unavailable, continuing to change regimens could provide satisfactory results.
Subject
Gastroenterology,Hepatology
Cited by
1 articles.
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