Impact of human papillomavirus status on survival in patients with oral cancer

Author:

Tangthongkum Manupol1ORCID,Phisalmongkhon Suwapat1,Leelasawatsuk Peesit1,Supanimitjaroenporn Pasawat1,Kirtsreesakul Virat1ORCID,Tantipisit Jarukit2

Affiliation:

1. Department of Otolaryngology Head and Neck Surgery Faculty of Medicine, Prince of Songkla University Hat Yai Songkhla Thailand

2. Department of Pathology Faculty of Medicine, Prince of Songkla University Hat Yai Songkhla Thailand

Abstract

AbstractObjectivesTo examine the association between the human papillomavirus (HPV) infection and overall survival rate in patients with oral cancer.MethodsThis retrospective cohort study examined HPV status in 454 patients who were diagnosed with oral squamous cell carcinoma (OSCC) using the records of patients who underwent an initial treatment for OSCC between 2012 and 2021 at our institution as retrieved from the Cancer Registry database. The survival rates of the HPV‐positive and HPV‐negative groups were assessed and compared, and independent factors associated with survival were analyzed using multivariate Cox regression models.ResultsOf the 454 patients with OSCC included in this study, 73 were excluded for invalid HPV tests. Of the remaining patients, 39 and 342 patients were categorized into HPV‐positive and HPV‐negative groups, respectively. The prevalence of HPV‐positive in the patients with OSCC was 10.2% (95% confidence interval 7.2%–13.2%). The 3‐year overall survival rates were 56.2% and 53.9% in the HPV‐positive and HPV‐negative groups, respectively. The 3‐year disease‐specific survival rates in the HPV‐positive and HPV‐negative groups were 60.2% and 56.9%, respectively. The survival differences were not statistically significant. HPV‐positive status was not a significant predictor of overall survival in the multivariable Cox regression analyses (p = 0.728).ConclusionThe prevalence of HPV‐positivity among patients with OSCC in the study was 10.2%. No association was found between HPV‐positive status and 3‐year overall survival in patients with oral cancer.Level of evidenceLevel 3.

Funder

Faculty of Medicine, Prince of Songkla University

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3