Exploiting the synergistic effects of combined carbon‐based materials for rape drug diazepam electrochemical sensing: Application to simulated casework matrices-Reference-Cited by-同舟云学术

Exploiting the synergistic effects of combined carbon‐based materials for rape drug diazepam electrochemical sensing: Application to simulated casework matrices

Published:2023-12-21 Issue: Volume: Page:
ISSN:1040-0397
Container-title:Electroanalysis
language:en
Short-container-title:Electroanalysis

Author:

de Oliveira Borges Isabelle¹^ORCID,Goularte Rayane Bueno¹^ORCID,Vanoni Caio Raphael¹^ORCID,Silva Lima Adriano Rogerio¹^ORCID,Scheide Marcos Roberto²^ORCID,Zambelli Mezalira Daniela³^ORCID,Vitali Luciano⁴^ORCID,Stulzer Hellen Karine⁵^ORCID,Jost Cristiane Luisa¹^ORCID

Affiliation:

1. ampere – Laboratório de Plataformas Eletroquímicas Departamento de Química Universidade Federal de Santa Catarina 88040-900 Florianópolis, SC Brazil

2. Departamento de Ciências Exatas e Educação Universidade Federal de Santa Catarina 89036-002 Blumenau, SC Brazil

3. Laboratory of Nanostructured and Catalytic Systems (LaSiNC) Departamento de Química Universidade Federal de Santa Catarina 88040-900 Florianópolis, SC Brazil

4. Departamento de Química Universidade Federal de Santa Catarina 88040-900 Florianópolis, SC Brazil

5. Departamento de Farmácia Universidade Federal de Santa Catarina 88040-900 Florianópolis, SC Brazil

Abstract

AbstractDiazepam (DZP), a long‐lasting benzodiazepine and controlled substance, is prevalent on the illegal market, notably as a date rape drug. This study presents a novel electrochemical sensor (CPE/GCPE/MWCNTs) for DZP determination in lab routines. Characterized through LSV, EIS, and SEM, the sensor revealed a pH‐dependent, irreversible reduction process at approximately −0.70 V (vs. Ag/AgCl(sat)). Optimization with SWV and 0.1 mol L−1 B–R solution (pH 1.0) produced a calibration curve spanning 1.49 to 21.5 μmol L−1. LOD and LOQ were 0.33 and 1.10 μmol L−1, respectively. Quantification in spiked samples exhibited no significant differences compared to HPLC‐DAD, endorsing the sensor for monitoring date rape drugs in forensic analysis.

Publisher

Wiley

Subject

Electrochemistry,Analytical Chemistry

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