Affiliation:
1. Department of Analytical Chemistry University of Chemistry and Technology Technická 5 16628 Prague 6 Czech Republic
2. Forensic Laboratory of Biologically Active Substances Department of Chemistry of Natural Compounds University of Chemistry and Technology Technická 3 16628 Prague Czech Republic
Abstract
AbstractThis work presents a potentiometric approach for the detection of two cathinone derivatives, namely mephedrone (4‐MMC) and clephedrone (4‐CMC). Contrary to neutral‐carriers (dibenzo‐18‐crown‐6‐ether and calix[4]arene), cation‐exchanger (tetraphenylborate sodium) as active component of ion‐selective membrane showed near‐Nernstian response (+47 mV/decade from 1.7 ⋅ 10−6 to 5.6 ⋅ 10−4 mol l−1) and selectivity for 4‐MMC in oral fluids (OF). The agreement between the quantitative results obtained with the potentiometric approach and the HPLC/MS‐MS method determination of 4‐MMC in OF shows the potential of the proposed potentiometric approach for forensic analysis.
Subject
Electrochemistry,Analytical Chemistry
Cited by
4 articles.
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