Volumetric measurements of weak current–induced magnetic fields in the human brain at high resolution

Author:

Göksu Cihan12,Gregersen Fróði134ORCID,Scheffler Klaus25ORCID,Eroğlu Hasan H.13ORCID,Heule Rahel25ORCID,Siebner Hartwig R.167,Hanson Lars G.13ORCID,Thielscher Axel13ORCID

Affiliation:

1. Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Amager and Hvidovre Copenhagen Denmark

2. High‐Field Magnetic Resonance Center Max‐Planck Institute for Biological Cybernetics Tübingen Germany

3. Section for Magnetic Resonance, DTU Health Tech Technical University of Denmark Kgs Lyngby Denmark

4. Sino‐Danish Center for Education and Research Aarhus Denmark

5. Department of Biomedical Magnetic Resonance University of Tübingen Tübingen Germany

6. Department of Neurology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark

7. Faculty of Medical and Health Sciences Institute for Clinical Medicine, University of Copenhagen Copenhagen Denmark

Abstract

AbstractPurposeClinical use of transcranial electrical stimulation (TES) requires accurate knowledge of the injected current distribution in the brain. MR current density imaging (MRCDI) uses measurements of the TES‐induced magnetic fields to provide this information. However, sufficient sensitivity and image quality in humans in vivo has only been documented for single‐slice imaging.MethodsA recently developed, optimally spoiled, acquisition‐weighted, gradient echo–based 2D‐MRCDI method has now been advanced for volume coverage with densely or sparsely distributed slices: The 3D rectilinear sampling (3D‐DENSE) and simultaneous multislice acquisition (SMS‐SPARSE) were optimized and verified by cable‐loop experiments and tested with 1‐mA TES experiments for two common electrode montages.ResultsComparisons between the volumetric methods against the 2D‐MRCDI showed that relatively long acquisition times of 3D‐DENSE using a single slab with six slices hindered the expected sensitivity improvement in the current‐induced field measurements but improved sensitivity by 61% in the Laplacian of the field, on which some MRCDI reconstruction methods rely. Also, SMS‐SPARSE acquisition of three slices, with a factor 2 CAIPIRINHA (controlled aliasing in parallel imaging results in higher acceleration) acceleration, performed best against the 2D‐MRCDI with sensitivity improvements for the and Laplacian noise floors of 56% and 78% (baseline without current flow) as well as 43% and 55% (current injection into head). SMS‐SPARSE reached a sensitivity of 67 pT for three distant slices at 2 × 2 × 3 mm3 resolution in 10 min of total scan time, and consistently improved image quality.ConclusionVolumetric MRCDI measurements with high sensitivity and image quality are well suited to characterize the TES field distribution in the human brain.

Funder

Deutsche Forschungsgemeinschaft

Lundbeck Foundation

Publisher

Wiley

Subject

Radiology, Nuclear Medicine and imaging

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