Prediction of Hepatobiliary Clearances and Hepatic Concentrations of Transported Drugs in Humans Using Rosuvastatin as a Model Drug-Reference-Cited by-同舟云学术

Prediction of Hepatobiliary Clearances and Hepatic Concentrations of Transported Drugs in Humans Using Rosuvastatin as a Model Drug

Published:2022-03-19 Issue:3 Volume:112 Page:593-604
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin Pharma and Therapeutics

Author:

Storelli Flavia¹,Li Cindy Yanfei¹,Sachar Madhav¹,Kumar Vineet¹,Heyward Scott²,Sáfár Zsolt³,Kis Emese³,Unadkat Jashvant D.¹

Affiliation:

1. Department of Pharmaceutics University of Washington Seattle Washington USA

2. BioIVT Baltimore Maryland USA

3. Solvo Biotechnology Szeged Hungary

Funder

Gilead Sciences

Amgen

Biogen

Genentech

Merck KGaA

Pfizer

Takeda Pharmaceuticals U.S.A.

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2556

Reference35 articles.

1. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1);Dresser M.J.;J. Pharmacol. Exp. Ther.,2000

2. Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

3. Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes

4. Interspecies Variability in Expression of Hepatobiliary Transporters across Human, Dog, Monkey, and Rat as Determined by Quantitative Proteomics

5. Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes;Frontiers in Pharmacology;2024-08-07

2. ISTransbase: an online database for inhibitor and substrate of drug transporters;Database;2024

3. Successful Prediction of Human Hepatic Concentrations of Transported Drugs Using the Proteomics‐Informed Relative Expression Factor Approach;Clinical Pharmacology & Therapeutics;2023-12-18

4. The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans;Pharmacology & Therapeutics;2022-10

5. Predicting Human Fetal Drug Exposure Through Maternal‐Fetal PBPK Modeling and In Vitro or Ex Vivo Studies;The Journal of Clinical Pharmacology;2022-09